[原发性高血压中的左心室质量与肾小球高滤过]
[Left ventricular mass and glomerular hyperfiltration in essential hypertension].
作者信息
du Cailar G, Ribstein J, Avignon A, Mimran A
机构信息
Policlinique, hôpital Lapeyronie, Montpellier.
出版信息
Arch Mal Coeur Vaiss. 1990 Jul;83(8):1161-4.
OBJECTIVE
to assess the early involvement to target organs in never treated essential hypertensives (HT).
METHODS
effective renal plasma flow (ERPF, 131I-Hippurate) and glomerular filtration rate (GFR, 99mTc-DTPA) were estimated in 80 mild HT. Left ventricular mass (LVM, M-mode echocardiography), sodium intake (24h UNaV) and urinary kallikrein (Kall) were also measured. Hyperfiltering patients (HF, GFR = 155 +/- 3 ml/min: 1.73 m2, n = 21) were defined by comparison with age-matched normotensive. HF patients were pair-matched for age, sex and blood pressure level with normofiltering hypertensives (NF, GFR = 112 +/- 3, n = 21).
RESULTS
are expressed as mean +/- sem [table: see text]
CONCLUSION
These results suggest that a high Na intake is associated with hyperfiltration and higher LVMI in subjects with never treated essential hypertension of short duration.
目的
评估初治原发性高血压（HT）患者靶器官的早期受累情况。
方法
对80例轻度高血压患者进行有效肾血浆流量（ERPF，131I-马尿酸盐）和肾小球滤过率（GFR，99mTc-DTPA）的评估。同时测量左心室质量（LVM，M型超声心动图）、钠摄入量（24小时尿钠排泄量）和尿激肽释放酶（Kall）。通过与年龄匹配的正常血压者比较，定义出超滤过患者（HF，GFR = 155±3 ml/min：1.73 m2，n = 21）。HF患者按年龄、性别和血压水平与正常滤过高血压患者（NF，GFR = 112±3，n = 21）进行配对。
结果
以均值±标准误表示[表格：见原文]
结论
这些结果表明，在病程较短的初治原发性高血压患者中，高钠摄入与超滤过及较高的左心室质量指数相关。
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