Schweitzer P, Pierrefiche O, Foutz A S, Denavit-Saubié M
Laboratoire de Physiologie Nerveuse, C.N.R.S., Gif-sur-Yvette, France.
Brain Res Dev Brain Res. 1990 Nov 1;56(2):290-3. doi: 10.1016/0165-3806(90)90095-g.
We gave newborn kittens the N-methyl-D-aspartate (NMDA) receptor blocker MK-801 systemically while recording their breathing patterns by the barometric method. Unlike pentobarbital, MK-801 at an anaesthetic dose increased the relative length of inspiration within the respiratory cycle. The section of both vagus nerves under MK-801 produced apneustic breathing, whereas vagotomy under pentobarbital had no such effect. We conclude that the central inspiratory-termination mechanism mediated through NMDA receptors and the vagally-mediated mechanism that independently 'switches off' inspiration are both functional at birth.
我们通过气压法记录新生小猫的呼吸模式时，对其进行了全身性的N-甲基-D-天冬氨酸（NMDA）受体阻滞剂MK-801给药。与戊巴比妥不同，麻醉剂量的MK-801增加了呼吸周期内吸气的相对时长。MK-801作用下切断双侧迷走神经会产生长吸式呼吸，而戊巴比妥作用下切断迷走神经则没有这种效果。我们得出结论，通过NMDA受体介导的中枢吸气终止机制和独立“关闭”吸气的迷走神经介导机制在出生时均起作用。
