Zimmerman R S, Martinez A J, MacPhee A A, Barbee R W
Ochsner Clinic, New Orleans, LA 70121.
Life Sci. 1990;47(25):2323-32. doi: 10.1016/0024-3205(90)90271-r.
Endothelin-3 (ET-3), a recently described vasoconstricting peptide was infused in Inactin anesthetized rats at 0, 40, 170 or 340 ng/kg/min for 45 minutes (n = 8 in each group). ET-3 infusion increased mean arterial pressure at all infusion rates by increasing total peripheral resistance. Cardiac output (delta CO) was significantly decreased at the two highest ET-3 infusion doses. The decrease in cardiac output was associated with a decrease in central venous pressure and stroke volume and an increase in hematocrit. ET-3 infusion at 40 ng/kg/min increased sodium excretion (delta UNaV) by 0.14 +/- 0.08 microEq/min (p less than 0.05 compared to vehicle infusion) without affecting the glomerular filtration rate (GFR). At higher infusion rates ET-3 markedly decreased the GFR, urine flow and urinary potassium excretion. ET-3 infusion significantly increased circulating levels of ANF. The present study demonstrates that ET-3 increases blood pressure by increasing total peripheral resistance but decreases cardiac output. Further, ET-3 has natriuretic effects at low doses but markedly attenuates renal function at high doses.
内皮素 - 3（ET - 3）是一种最近被描述的血管收缩肽，以0、40、170或340 ng/kg/分钟的速率在因纳克（Inactin）麻醉的大鼠中输注45分钟（每组n = 8）。ET - 3输注通过增加总外周阻力在所有输注速率下均升高平均动脉压。在两个最高的ET - 3输注剂量下，心输出量（ΔCO）显著降低。心输出量的降低与中心静脉压和每搏输出量的降低以及血细胞比容的增加有关。以40 ng/kg/分钟的速率输注ET - 3可使钠排泄量（ΔUNaV）增加0.14±0.08微当量/分钟（与载体输注相比，p＜0.05），而不影响肾小球滤过率（GFR）。在较高的输注速率下，ET - 3显著降低GFR、尿流和尿钾排泄。ET - 3输注显著增加了心房利钠因子（ANF）的循环水平。本研究表明，ET - 3通过增加总外周阻力升高血压，但降低心输出量。此外，ET - 3在低剂量时有利钠作用，但在高剂量时显著减弱肾功能。
