Department Physiology and Pharmacology, Sapienza University, Rome, Italy.
Res Dev Disabil. 2011 Sep-Oct;32(5):1792-7. doi: 10.1016/j.ridd.2011.03.008. Epub 2011 Apr 8.
Inhibition of inappropriate responses allows to shape the motor behavior accordingly to the context in which a subject acts and is an essential executive function. Inhibition has been poorly investigated in Down Syndrome (DS) patients. We tested, using a countermanding task, the inhibitory control in a group of DS patients and in a group of patients with developmental disorders of non-genetic etiology, matched for mental age. We found that the duration of the stopping process, the stop signal reaction time (SSRT), was not statistically different in the two groups of patients. At the same time, the normalized inhibitory function resulted shallower in DS patients indicating a poor inhibitory control. We interpreted the results on the basis of the known anatomical differences in the brain of adult DS patients and more specifically in a possible altered dialogue between the fronto-striatal and fronto-cerebellar networks during motor control.
抑制不适当的反应可以使主体的运动行为适应其所处的环境，这是一种重要的执行功能。在唐氏综合征（DS）患者中，对抑制的研究较少。我们使用反命令任务测试了一组 DS 患者和一组具有非遗传病因的发育障碍患者的抑制控制能力，这些患者的智力年龄相匹配。我们发现，两组患者的停止过程持续时间（SSRT）没有统计学差异。同时，DS 患者的抑制功能标准化值较浅，表明其抑制控制能力较差。我们根据成年 DS 患者大脑的已知解剖差异以及更具体的在运动控制过程中额-纹状体和额-小脑网络之间可能存在的改变对话来解释结果。
