Paleiron N, Bizien N, Vinsonneau U, Andre M, Grassin F
Service de pneumologie, hôpital d'Instruction des Armées Clermont-Tonnerre, rue du Colonel-Fonferrier, Brest, France.
Rev Mal Respir. 2011 Mar;28(3):352-4. doi: 10.1016/j.rmr.2010.08.014. Epub 2011 Mar 1.
Itraconazole is an azole derivative used for the treatment of aspergillosis. Cardiac failure is a rare complication of treatment. Most cases occur in patients with cardiovascular risk factors, or taking multiple medications, and a causal relationship is not well-established.
We report the case of a patient, without cardiovascular risk factors, presenting with cardiac failure during treatment with itraconazole. Pre-treatment stress testing and echocardiography were normal. Resolution was complete without sequelae.
Cardiac failure can occur in association with itraconazole despite normal cardiological investigations before treatment.
伊曲康唑是一种用于治疗曲霉病的唑类衍生物。心力衰竭是一种罕见的治疗并发症。大多数病例发生在有心血管危险因素或正在服用多种药物的患者中，因果关系尚未明确。
我们报告一例患者，无心血管危险因素，在接受伊曲康唑治疗期间出现心力衰竭。治疗前的应激试验和超声心动图检查均正常。心力衰竭完全缓解，无后遗症。
尽管治疗前心脏检查正常，但伊曲康唑治疗仍可能并发心力衰竭。
