Savolainen H, Salo J O, Verkkala K, Holmström T, Lehtola A, Schröder T
Department of Thoracic and Cardiovascular Surgery, University Central Hospital, Helsinki, Finland.
Ann Chir Gynaecol. 1990;79(3):147-52.
The healing of an arterial lesion created by continuous wave contact Nd:YAG laser was investigated. Normal arterial walls were irradiated. It is nearly impossible to irradiate atheromatous plaques without involving adjacent normal arterial wall as well. The purpose of this study was to evaluate the healing process using a standard thermal laser. Different power outputs were used with 1.0 sec exposure. A cw Nd:YAG laser with a wavelength of 1064 nm was used. Eighteen piglets underwent laparotomy. An 0.6 mm fibre with a rounded 2.2 mm sapphire probe was introduced into the aorta and iliac arteries. The irradiation was performed vertically to the vessel wall. The artery specimens were studied histologically and through electron scanning microscopy. Immediately after irradiation, adherence of platelets was observed. At two days the core centre was invaded with mononuclear blood cells and polymorphonuclear leukocytes. At five days there was still some denudation of endothelium, and the initial debris started to disappear. At two weeks medial smooth muscle cells were seen around the necrotic zone. The area was encapsulated by layers of smooth muscle and collagen. The healing process seems similar to that of mechanical injury of the aortic intima.
研究了连续波接触式Nd:YAG激光造成的动脉损伤的愈合情况。对正常动脉壁进行了照射。由于几乎不可能在不涉及相邻正常动脉壁的情况下照射动脉粥样硬化斑块，本研究的目的是使用标准热激光评估愈合过程。采用不同的功率输出，曝光时间为1.0秒。使用波长为1064nm的连续波Nd:YAG激光。18只仔猪接受了剖腹手术。将一根带有2.2mm圆形蓝宝石探头的0.6mm光纤插入主动脉和髂动脉。垂直于血管壁进行照射。对动脉标本进行了组织学和电子扫描显微镜研究。照射后立即观察到血小板黏附。两天时，核心部位有单核血细胞和多形核白细胞侵入。五天时，仍有一些内皮剥脱，最初的碎片开始消失。两周时，在坏死区周围可见中层平滑肌细胞。该区域被平滑肌和胶原层包裹。愈合过程似乎与主动脉内膜机械损伤的愈合过程相似。
