荟萃分析表明，DISC1 基因座的常见变异与精神分裂症无关。

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

Mol Psychiatry. 2012 Jun;17(6):634-41. doi: 10.1038/mp.2011.41. Epub 2011 Apr 12.

Several polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to be associated with schizophrenia. However, to date, there has been little effort to evaluate the evidence for association systematically. We carried out an imputation-driven meta-analysis, the most comprehensive to date, using data collected from 10 candidate gene studies and three genome-wide association studies containing a total of 11 626 cases and 15 237 controls. We tested 1241 single-nucleotide polymorphisms in total, and estimated that our power to detect an effect from a variant with minor allele frequency >5% was 99% for an odds ratio of 1.5 and 51% for an odds ratio of 1.1. We find no evidence that common variants at the DISC1 locus are associated with schizophrenia.

几种精神分裂症相关蛋白 1（DISC1）基因的多态性与精神分裂症有关。然而，迄今为止，很少有系统评估其关联性的努力。我们进行了迄今为止最全面的基于基因分型的荟萃分析，使用了来自 10 项候选基因研究和 3 项全基因组关联研究的数据，共包含 11626 例病例和 15237 例对照。我们总共测试了 1241 个单核苷酸多态性，估计我们检测频率大于 5%的等位基因频率为 1.5 的变异的效力为 99%，检测等位基因频率为 1.1 的变异的效力为 51%。我们没有发现 DISC1 基因座的常见变异与精神分裂症有关。