The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase.
作者信息
Chen Nan, Rinner Oliver, Czernik Dominika, Nytko Katarzyna J, Zheng Dan, Stiehl Daniel P, Zamboni Nicola, Gstaiger Matthias, Frei Christian
出版信息
Cell Res. 2011 Jun;21(6):983-6. doi: 10.1038/cr.2011.66. Epub 2011 Apr 12.
Abstract
摘要
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The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase.氧传感器 PHD3 通过直接结合丙酮酸激酶在缺氧条件下限制糖酵解。
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Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells.丙酮酸激酶 M2 型：肿瘤细胞代谢预算系统的关键调节因子。
Int J Biochem Cell Biol. 2011 Jul;43(7):969-80. doi: 10.1016/j.biocel.2010.02.005. Epub 2010 Feb 13.
2
Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors.氧传感器PHD-1、PHD-2、PHD-3和FIH的过表达与胰腺内分泌肿瘤的肿瘤侵袭性相关。
Clin Cancer Res. 2008 Oct 15;14(20):6634-9. doi: 10.1158/1078-0432.CCR-07-5258.
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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.后生动物的氧感应：HIF羟化酶途径的核心作用。
Mol Cell. 2008 May 23;30(4):393-402. doi: 10.1016/j.molcel.2008.04.009.
4
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.丙酮酸激酶的M2剪接异构体对癌症代谢和肿瘤生长很重要。
Nature. 2008 Mar 13;452(7184):230-3. doi: 10.1038/nature06734.
5
Regulated function of the prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins.脯氨酰-4-羟化酶结构域（PHD）氧感应蛋白的调控功能。
Antioxid Redox Signal. 2007 Sep;9(9):1329-38. doi: 10.1089/ars.2007.1683.
6
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.肿瘤丙酮酸激酶M2变构调节与催化的结构基础
Biochemistry. 2005 Jul 12;44(27):9417-29. doi: 10.1021/bi0474923.
7
Why do cancers have high aerobic glycolysis?为什么癌症具有高有氧糖酵解现象？
Nat Rev Cancer. 2004 Nov;4(11):891-9. doi: 10.1038/nrc1478.
8
The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.低氧诱导因子脯氨酰羟化酶PHD3是TRiC伴侣蛋白的潜在底物。
FEBS Lett. 2004 Jul 16;570(1-3):166-70. doi: 10.1016/j.febslet.2004.06.040.
9
Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth.果蝇细胞周期蛋白D/细胞周期蛋白依赖性激酶4需要低氧诱导因子-1脯氨酰羟化酶来驱动细胞生长。
Dev Cell. 2004 Feb;6(2):241-51. doi: 10.1016/s1534-5807(03)00409-x.
10
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.缺氧诱导因子脯氨酰羟化酶2是在常氧状态下使缺氧诱导因子-1α维持低稳态水平的关键氧感受器。
EMBO J. 2003 Aug 15;22(16):4082-90. doi: 10.1093/emboj/cdg392.
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