rs6983267 多态性与中国人群胃癌风险的关联。
Association between polymorphism rs6983267 and gastric cancer risk in Chinese population.
机构信息
Department of Gastroenterology, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, China.
出版信息
World J Gastroenterol. 2011 Apr 7;17(13):1759-65. doi: 10.3748/wjg.v17.i13.1759.
AIM
To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk.
METHODS
A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer.
RESULTS
The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753; OR: 1.916, 95% CI: 1.166-3.150, respectively).
CONCLUSION
This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed.
目的
探讨 8q24 单核苷酸多态性（SNP）与胃癌风险的关联。
方法
进行了一项包括 212 例胃癌患者和 377 例健康对照的病例对照研究。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）检测和建立 SNP（rs6983267、rs7008482 和 rs10808555）的基因型。采用多变量 logistic 回归模型评估 SNP 与胃癌之间的关联。
结果
胃癌患者 rs6983267 的基因型频率明显不同于对照组（P = 0.005）。与 GG 基因型相比，rs6983267 的 GT 基因型与胃癌的风险增加相关（调整后的优势比=2.01，95%置信区间：1.28-3.14）。进一步的分层分析表明，rs6983267 GT 基因型增加了非贲门和肠型胃癌的风险（OR：2.638，95%CI：1.464-4.753；OR：1.916，95%CI：1.166-3.150）。
结论
本研究首次表明 rs6983267 参与了胃癌的易感性，但仍需要进一步的大样本研究。
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