Research Institute of Stomatology, Nanjing Medical University, Jiangsu, China.
Int J Oral Maxillofac Implants. 2011 Mar-Apr;26(2):333-40.
This study evaluated the biologic response to titanium mesh and autogenous particulate bone grafts for the reconstruction of segmental mandibular defects in a dog model.
Unilateral 40-mm critical-sized continuity defects of the mandible were made in five beagle dogs. Titanium mesh was shaped and fixed with titanium screws in the defects. Autogenous bone was harvested from the ablated mandible and iliac crest (the ratio of cortical bone:cancellous bone was 3:1) and used to fill the mesh. Two implants were placed into each bone graft. The animals were sacrificed after 6 months. Radiographs, histologic sections, scanning electron microscopy, and energy dispersive spectroscopy were performed to evaluate bone formation and osseointegration of the implants in the reconstructed mandibles.
The outline of the reconstructed mandible was satisfactory, and no bone resorption was observed in the defect area. All implants showed excellent osseointegration of the grafted bone. Furthermore, the density of bone formed around the implants was higher than that seen in control samples (intact, ungrafted dog hemimandibles).
Shaped titanium mesh with autogenous particulate bone graft is a predictable method for restoring critical-sized continuity defects of the mandible. Simultaneous implant placement is feasible and the structure of bone formed near implants may be optimal.
本研究通过犬模型评估钛网和自体颗粒骨移植修复下颌骨节段性缺损的生物学反应。
在 5 只比格犬中制作单侧 40mm 临界尺寸连续性下颌骨缺损。钛网用钛螺钉塑形并固定在缺损处。自体骨取自消融的下颌骨和髂嵴（皮质骨：松质骨的比例为 3:1），并用于填充网。每个骨移植物中放置 2 个植入物。动物在 6 个月后被处死。进行 X 线摄影、组织学切片、扫描电子显微镜和能量色散光谱检查，以评估重建下颌骨中植入物的骨形成和骨整合情况。
重建下颌骨的轮廓令人满意，在缺损区域未观察到骨吸收。所有植入物均显示出对移植物骨的良好骨整合。此外，在植入物周围形成的骨密度高于对照组（完整、未移植的犬半下颌骨）。
形状的钛网与自体颗粒骨移植物是修复下颌骨临界尺寸连续性缺损的一种可预测方法。同时进行植入物放置是可行的，并且植入物附近形成的骨结构可能是最佳的。
