Department of Chemistry, National University of Singapore, Singapore.
Org Biomol Chem. 2011 May 21;9(10):3691-7. doi: 10.1039/c1ob05404j. Epub 2011 Apr 11.
An efficient, convenient and enantioselective Michael-hemiketalization reaction has been developed for the synthesis of naphthoquinones. In this work, a novel trans-bifunctional indane thiourea catalyst has been reported to promote this process to afford high yields (up to 99%) and high to excellent enantiomeric excesses (90-98% ee).
一种高效、便捷和对映选择性的迈克尔-半缩酮化反应已被开发用于合成萘醌。在这项工作中，报道了一种新型的反式双功能茚烷硫脲催化剂来促进这个过程，以提供高产率（高达 99%）和高至优秀的对映体过量（90-98%ee）。
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