β,γ-不饱和酮酸酯与α-硝基酮的不对称有机催化级联 Michael/半缩醛化/反 Henry 反应。
Asymmetric organocatalytic cascade Michael/hemiketalization/retro-Henry reaction of β,γ-unsaturated ketoesters with α-nitroketones.
机构信息
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
出版信息
Chem Commun (Camb). 2011 May 28;47(20):5819-21. doi: 10.1039/c1cc11124h. Epub 2011 Apr 12.
PMID:21487613
Abstract
An unprecedented enantioselective organocatalytic Michael/hemiketalization/retro-Henry cascade sequence is described, which catalyzed by a simple bifunctional indane amine-thiourea catalyst. This process provides a new route to the enantioselective synthesis of 5-nitro-pent-2-enoates, a precursor to α-ketolactam.
摘要
本文描述了首例非对映选择性的有机催化迈克尔加成/半缩醛化/反 Henry 级联反应序列，该反应由一种简单的双功能茚满胺-硫脲催化剂催化。该过程为对映选择性合成 5-硝基戊-2-烯酸酯（α-酮内酯的前体）提供了新途径。
Zotero 插件