免疫功能正常患者中伪装成眼内肿瘤的孤立性葡萄膜结核瘤——一项通过聚合酶链反应诊断的临床病理研究
Isolated uveal tuberculoma masquerading as an intraocular tumor in an immunocompetent patient-a clinical-pathologic study with diagnosis by PCR.
作者信息
Marback Eduardo F, de Souza Mendes Epaminondas, Chagas Oliveira Ricardo D, Parikh Jignesh G, Rao Narsing A
机构信息
Federal University of Bahia, Salvador, Bahia, Brazil,
出版信息
J Ophthalmic Inflamm Infect. 2011 Jun;1(2):81-4. doi: 10.1007/s12348-010-0010-x. Epub 2010 Nov 17.
PURPOSE
The aim of this article is to report a case of uveal tuberculoma simulating an intraocular tumor in which the diagnosis was only possible by polymerase chain reaction (PCR) analysis.
METHOD
This is a case report.
RESULTS
A36-year-old male presented with a progressive growing intraocular tumor and no history or positive test for other systemic disease. The eye eventually turned blind and painful and was enucleated. Histopathologic analysis revealed a granulomatous reaction and caseation necrosis but failed to identify any causative microorganisms. Final tuberculosis diagnosis was only possible by quantitative PCR.
CONCLUSION
Isolated uveal tuberculoma can present in an otherwise healthy patient with negative systemic tuberculosis evaluation. PCR can be used to confirm tuberculosis when other methods have failed.
目的
本文旨在报告一例模拟眼内肿瘤的葡萄膜结核瘤病例，该病例仅通过聚合酶链反应（PCR）分析才得以确诊。
方法
这是一篇病例报告。
结果
一名36岁男性患者出现一个进行性生长的眼内肿瘤，无其他全身性疾病史或相关阳性检查结果。患眼最终失明且疼痛，遂行眼球摘除术。组织病理学分析显示有肉芽肿反应和干酪样坏死，但未发现任何致病微生物。最终仅通过定量PCR才确诊为结核病。
结论
孤立性葡萄膜结核瘤可出现在全身结核病评估为阴性的健康患者中。当其他方法均失败时，PCR可用于确诊结核病。
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