托珠单抗治疗过程中并发鸟分枝杆菌感染的类风湿关节炎 1 例报告
A case report of a patient with rheumatoid arthritis complicated with Mycobacterium avium during tocilizumab treatment.
机构信息
Division of Allergy, Rheumatology and Connective Tissue Diseases, Department of Internal Medicine, NTT West Osaka Hospital, 2-6-40 Karasugatsuji, Tennoji-ku, Osaka 543-8922, Japan.
出版信息
Mod Rheumatol. 2011 Dec;21(6):655-9. doi: 10.1007/s10165-011-0448-1. Epub 2011 Apr 12.
A female patient with rheumatoid arthritis (RA) suffered from Mycobacterium avium (M. avium) infection during tocilizumab treatment. Tocilizumab was discontinued and she was treated with a recommended chemotherapy, resulting in improvement of M. avium. Tocilizumab retreatment did not aggravate M. avium infection, and radiographic abnormalities improved over 1 year after cessation of the recommended therapy. Tocilizumab may be one candidate for intractable RA patients with M. avium if any biologic is required.
一位患有类风湿关节炎（RA）的女性患者在接受托珠单抗治疗期间发生鸟分枝杆菌（M. avium）感染。停用托珠单抗后，给予推荐的化疗，M. avium 得到改善。托珠单抗再治疗并未加重 M. avium 感染，且在停止推荐治疗后 1 年内影像学异常得到改善。如果需要使用任何生物制剂，托珠单抗可能是治疗难治性 M. avium 感染 RA 患者的候选药物之一。
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