二甲双胍或奥利司他对多囊卵巢综合征肥胖女性的影响：一项前瞻性随机开放标签研究。
The effects of metformin or orlistat on obese women with polycystic ovary syndrome: a prospective randomized open-label study.
机构信息
Department of Obstetrics & Gynecology, Sabzevar University of Medical Sciences, Sabzevar, Iran.
出版信息
J Assist Reprod Genet. 2011 Jul;28(7):591-6. doi: 10.1007/s10815-011-9564-2. Epub 2011 Apr 12.
Abstract
PURPOSE
Comparing the effects of metformin or orlistat on hormone, lipid profile and ovulation status in obese women with polycystic ovary syndrome.
METHODS
A total of 80 women were prospectively recruited to receive either metformin (n = 40) or orlistat (n = 40). Weight, BMI, waist, serum LH, total serum testosterone and lipid profile were assessed at baseline and after 3 months. The subjects' ovulatory status was assessed after 3 months.
RESULTS
There was no significant difference in ovulation between the two treatment groups (30% vs 15%). Treatment with either drug showed a significant decline in body weight, BMI (Body Mass Index), and waist circumference, but the degree of decline in both groups was the same. Patients who were treated with orlistat, showed a significant reduction in total testosterone and serum lipid. Women in metformin group showed a significant reduction in serum LH.
CONCLUSIONS
Both metformin and orlistat showed a similar effect on weight loss and ovulation rates.
摘要
目的
比较二甲双胍或奥利司他对多囊卵巢综合征肥胖妇女激素、血脂谱和排卵状态的影响。
方法
前瞻性招募 80 名女性，分别接受二甲双胍（n = 40）或奥利司他（n = 40）治疗。在基线和 3 个月后评估体重、BMI、腰围、血清 LH、总血清睾酮和血脂谱。3 个月后评估受试者的排卵状态。
结果
两组的排卵率无显著差异（30%比 15%）。两种药物治疗均显著降低体重、BMI（体重指数）和腰围，但两组的下降程度相同。奥利司他治疗组总睾酮和血清脂质显著降低。二甲双胍组女性血清 LH 显著降低。
结论
二甲双胍和奥利司他在减肥和排卵率方面均有相似的效果。
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