The Russell H. Morgan Department of Radiology, Division of Nuclear Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Eur J Nucl Med Mol Imaging. 2011 May;38 Suppl 1(Suppl 1):S41-7. doi: 10.1007/s00259-011-1769-1. Epub 2011 Apr 12.
Radioiodine therapy of thyroid cancer was the first and remains among the most successful radiopharmaceutical (RPT) treatments of cancer although its clinical use is based on imprecise dosimetry. The positron emitting radioiodine, (124)I, in combination with positron emission tomography (PET)/CT has made it possible to measure the spatial distribution of radioiodine in tumors and normal organs at high resolution and sensitivity. The CT component of PET/CT has made it simpler to match the activity distribution to the corresponding anatomy. These developments have facilitated patient-specific dosimetry (PSD), utilizing software packages such as three-dimensional radiobiological dosimetry (3D-RD), which can account for individual patient differences in pharmacokinetics and anatomy. We highlight specific examples of such calculations and discuss the potential impact of (124)I PET/CT on thyroid cancer therapy.
放射性碘治疗甲状腺癌是最早的也是目前为止最成功的放射性药物(RPT)治疗癌症的方法之一,尽管其临床应用是基于不精确的剂量测定。正电子发射放射性碘(124)I 与正电子发射断层扫描(PET)/计算机断层扫描(CT)结合使用,使得能够以高分辨率和灵敏度测量肿瘤和正常器官中放射性碘的空间分布。PET/CT 的 CT 成分使得更容易将活性分布与相应的解剖结构相匹配。这些发展促进了个体化剂量测定(PSD),利用三维放射生物学剂量测定(3D-RD)等软件包,这些软件包可以考虑个体患者在药代动力学和解剖结构方面的差异。我们强调了这些计算的具体示例,并讨论了(124)I PET/CT 对甲状腺癌治疗的潜在影响。