Lechleitner P, Dzien A, Haring C, Glossmann H
Department of Internal Medicine, University of Innsbruck, Austria.
Toxicology. 1990 Dec 3;64(3):325-9. doi: 10.1016/0300-483x(90)90124-y.
A 43-year-old patient with mild heart failure attempted suicide by ingesting between 5000 and 7500 mg of captopril. Blood pressure oscillated around 100-120/50-75 mmHg and pulse rate showed no tendency to accelerate (75-100/min). The psychiatric examination showed no drug induced psychopathological symptoms. The calculated half-life of captopril was 4.4 h. Seven hours after ingestion of approximately 50 times the maximal therapeutic daily dose of captopril the serum concentration reached 20 micrograms/ml. The calculated amount of absorbed captopril was approximately 5400 mg. Atrial natriuretic factor (ANF) plasma levels were slightly elevated and showed no tendency to increase or to fall.
一名43岁轻度心力衰竭患者吞服了5000至7500毫克卡托普利企图自杀。血压在100 - 120/50 - 75毫米汞柱之间波动，脉搏率无加快趋势（75 - 100次/分钟）。精神检查未发现药物诱发的精神病理症状。计算得出卡托普利的半衰期为4.4小时。在摄入约为卡托普利最大治疗日剂量50倍的药物7小时后，血清浓度达到20微克/毫升。计算得出吸收的卡托普利量约为5400毫克。心房利钠因子（ANF）血浆水平略有升高，且无升高或下降趋势。
