鬼火：CCN4 作为骨关节炎的新型分子靶点。
Will o' the wisp: CCN4 as a novel molecular target in osteoarthritis.
机构信息
Department of Dentistry, University of Western Ontario, London, ON, Canada, NGA 5C1,
出版信息
J Cell Commun Signal. 2011 Mar;5(1):51-2. doi: 10.1007/s12079-010-0110-2. Epub 2010 Dec 1.
Abstract
Osteoarthritis (OA), or degenerative arthritis, is characterized by mechanical stress-induced changes in cartilage and bone. OA is a leading cause of chronic disability in North America and Europe. A recent study written by Blom and colleagues (Arthritis and Rheumatism 2009; 60:501-12) showed that elevated wnt signaling was observed in experimental OA as well as in patient samples. The authors found that the known wnt target WISP-1 (CCN4) was also overexpressed; CCN4 was sufficient to recapitulate an OA phenotype in vitro and in vivo, suggesting that CCN4 may be a novel target for drug intervention in OA. This commentary summarizes these exciting findings.
摘要
骨关节炎（OA），又称退行性关节炎，其特征为软骨和骨的机械性应激诱导改变。OA 是北美和欧洲慢性失能的主要原因。Blom 及其同事最近发表的一项研究（关节炎与风湿病 2009；60：501-12）显示，实验性 OA 以及患者样本中均观察到升高的 wnt 信号。作者发现，已知的 wnt 靶标 WISP-1（CCN4）也过表达；CCN4 足以在体外和体内重现 OA 表型，表明 CCN4 可能是 OA 药物干预的新靶点。这篇评论总结了这些令人兴奋的发现。
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