Institute of Neurology, Università Cattolica del Sacro Cuore, Largo F Vito 1, Rome 00168, Italy.
Muscle Nerve. 2011 May;43(5):652-6. doi: 10.1002/mus.21935.
The purpose of this study was to determine whether single-fiber conduction velocity (SF-CV) of a small number of axons increases sensitivity for identification of motor nerve conduction alterations in patients with diabetes.
Twenty-one consecutive diabetic patients in good metabolic control were studied. For each patient, conventional (C-CV) and SF-CV results were correlated with the presence of neuropathic symptoms.
Nine of 21 patients reported symptoms suggestive of mild nerve impairment. Three patients had abnormal sural nerve CV, 1 of whom also had abnormal motor nerve conduction. Eighteen patients had normal findings on conventional tests, 3 of whom had slowing of SF-CV.
SF-CV is able to detect mild myelin damage with higher sensitivity than conventional tests. The use of SF-CV may be a helpful tool in the early identification of diabetic polyneuropathy, and it may be useful for tailoring an approach to diabetic polyneuropathy.
本研究旨在确定少数轴突的单纤维传导速度（SF-CV）是否能提高对糖尿病患者运动神经传导改变的识别敏感性。
研究了 21 例连续的代谢控制良好的糖尿病患者。对于每位患者，常规（C-CV）和 SF-CV 结果均与神经病变症状的存在相关。
21 例患者中有 9 例报告有提示轻度神经损伤的症状。3 例患者的腓肠神经 CV 异常，其中 1 例运动神经传导也异常。18 例患者常规检查结果正常，其中 3 例 SF-CV 减慢。
SF-CV 比常规检查更能灵敏地检测轻度脱髓鞘损伤。SF-CV 的应用可能有助于早期发现糖尿病多发性神经病，并有助于制定针对糖尿病多发性神经病的治疗方法。
