Graduate Institute of Oral Biology and Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
Head Neck. 2012 Apr;34(4):505-12. doi: 10.1002/hed.21761. Epub 2011 Apr 11.
Previous studies found that topical photodynamic therapy (PDT) is very effective for human oral precancerous lesions.
This study evaluated whether topical photosan-mediated PDT (topical photosan-PDT), using a 640-nm light-emitting diode (LED) light, is an effective treatment modality for hamster buccal pouch precancerous lesions. Fourteen 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch precancerous lesions were treated with topical photosan-PDT using the 640-nm LED light twice a week.
All 14 of the precancerous lesions showed a complete histologically confirmed response to the lesions after an average of 3.79 (range, 3-5) PDT treatments. Normal and precancerous pouch mucosae in the other 4 hamsters received 17 or 19 treatments of topical photosan-PDT showed no cumulative side effects. No recurrence of the lesions was found in these 18 PDT-treated hamsters after a follow-up period of 50 weeks.
Our findings indicate that topical photosan-PDT is a very effective treatment modality for DMBA-induced hamster buccal pouch precancerous lesions.
先前的研究发现，局部光动力疗法（PDT）对人类口腔癌前病变非常有效。
本研究评估了使用 640nm 发光二极管（LED）光的局部光敏剂介导的 PDT（局部光敏剂-PDT）是否是治疗仓鼠颊囊癌前病变的有效治疗方法。用 DMBA 诱导的 14 只仓鼠颊囊癌前病变，每周两次用 640nm LED 光进行局部光敏剂-PDT 治疗。
所有 14 个癌前病变在平均 3.79（范围 3-5）次 PDT 治疗后，均获得了完全的组织学确认应答。另外 4 只仓鼠的正常和癌前囊黏膜接受了 17 或 19 次局部光敏剂-PDT 治疗，没有累积的副作用。在 50 周的随访期内，18 只接受 PDT 治疗的仓鼠未发现病变复发。
我们的研究结果表明，局部光敏剂-PDT 是治疗 DMBA 诱导的仓鼠颊囊癌前病变的一种非常有效的治疗方法。
