Johns Hopkins University, 2024 East Monument Street, Baltimore,MD 21287, USA.
Arthritis Care Res (Hoboken). 2011 Aug;63(8):1108-14. doi: 10.1002/acr.20479.
Obesity is associated with gout risk. It is unclear whether obesity is associated with a younger age at gout onset. We examined whether obesity is related to age at gout onset and quantified the risk of incident gout by obesity status in the Campaign Against Cancer and Heart Disease (CLUE II) study, a longitudinal community-based cohort.
CLUE II began in 1989 as a cohort study of residents living within or surrounding Washington County, Maryland. Followup questionnaires queried whether each participant had been diagnosed as having gout by a health care professional. Among participants with gout, we assessed whether obesity was related to age at disease onset. We also ascertained the 18-year risk of incident gout according to obesity status (body mass index ≥30 kg/m(2) ) at baseline with cumulative incidence ratios (RRs) and 95% confidence intervals (95% CIs) from Poisson regression.
Among the study population (n = 15,533), 517 persons developed incident gout. The prevalence of obesity at baseline was 16.2%. The overall mean age at gout onset was 59.3 years. The onset of gout was 3.1 years (95% CI 0.3, 5.8) earlier in those who were obese at baseline and 11.0 years earlier (95% CI 5.8, 16.1) in participants who were obese at age 21 years, as compared with the nonobese participants. The 18-year adjusted RR of gout in obese participants compared with nonobese participants was 1.92 (95% CI 1.55, 2.37).
Obesity is not only a risk factor for incident gout but is associated with an earlier age at gout onset.
肥胖与痛风风险相关。肥胖是否与痛风发病年龄较早有关尚不清楚。我们在癌症和心脏病防治研究（CLUE II）中检查了肥胖是否与痛风发病年龄有关，并按肥胖状况量化了肥胖人群中痛风发病的风险，这是一项基于社区的纵向队列研究。
CLUE II 于 1989 年作为马里兰州华盛顿县及其周边地区居民的队列研究开始。后续问卷调查了每位参与者是否被医疗保健专业人员诊断为患有痛风。在患有痛风的参与者中，我们评估了肥胖是否与疾病发病年龄有关。我们还根据基线时肥胖状况（体重指数≥30kg/m2）评估了肥胖状况与痛风发病风险的 18 年关联，使用泊松回归计算累积发病率比（RR）和 95%置信区间（95%CI）。
在研究人群（n=15533）中，有 517 人发生了痛风。基线时肥胖的患病率为 16.2%。痛风发病的平均年龄为 59.3 岁。与非肥胖参与者相比，基线时肥胖的参与者痛风发病年龄提前了 3.1 年（95%CI 0.3，5.8），而 21 岁时肥胖的参与者痛风发病年龄提前了 11.0 年（95%CI 5.8，16.1）。与非肥胖参与者相比，肥胖参与者 18 年调整后的痛风发病 RR 为 1.92（95%CI 1.55，2.37）。
肥胖不仅是痛风发病的危险因素，而且与痛风发病年龄较早有关。
