Renaguli Aizezi, Meryemgul Mijit, Abudoureyimu Shajidan
Faculty of Traditional Uighur Medicine, Xinjiang Medical University, Urumqi.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Mar;31(3):346-9.
To study the correlation between prethrombotic biomarkers and traditional Uyghur medicinal syndromes of malignant tumor.
One hundred and fifty-nine malignant tumor inpatients were randomly selected and typed according to traditional Uyghur medicine theories. The expressions of peripheral platelet membrane glucoprotein (CD41 and CD62p), levels of serum endothelin (ET-1), plasma tissue plasminogen activator (t-PA), plasminogen activator inhibitor (PAI), plasma fibrinogen (FIB), prothrombin time (PT), and thrombin time (TT), and activated partial thromboplastin time (APTT) were detected by flow cytometry, radioimmunoassay, and enzyme-linked immunosorbent assay (ELISA) respectively.
The patients were typed as 68 of abnormal Savda syndrome, 34 of abnormal Khan syndrome, 31 of the abnormal Sepra syndrome, and 26 of the abnormal Belghem syndrome. Compared with the control group, the levels of CD62p, PAI, and ET-1 increased, levels of FIB and t-PA decreased, PT prolongated and APTT shortened in the abnormal Savda group and the non-abnormal Savda group (including abnormal Khan, abnormal Sepra, and abnormal Belghem types) (all P < 0.05). No significant difference of CD41 or TT was shown in inter-group comparison (P > 0.05). Compared with abnormal Khan and Belghem groups, the ET-1 level increased in the abnormal Savda group (P < 0.05). Compared with the abnormal Sepra group, the CD62p positive percentage increased in abnormal Savda group (P < 0.05). No significant difference in CD41 positive percentage, t-PA or PAI-1 contents, PT, TT, or APTT was shown in patients of different traditional Uyghur medicine syndrome groups (P > 0.05).
Prethrombotic changes existed in malignant tumor patients of different Uyghur abnormal syndrome types, manifested as injuries of vessel epithelial cells, platelet activation, increased blood viscosity, lowered fibrinolytic function. The prethrombotic changes were more obviously seen in the abnormal Savda group.
研究血栓前生物标志物与恶性肿瘤维吾尔医传统病症之间的相关性。
随机选取159例恶性肿瘤住院患者，依据维吾尔医传统理论进行分型。分别采用流式细胞术、放射免疫分析法及酶联免疫吸附测定法（ELISA）检测外周血血小板膜糖蛋白（CD41和CD62p）表达、血清内皮素（ET-1）水平、血浆组织型纤溶酶原激活剂（t-PA）、纤溶酶原激活剂抑制剂（PAI）、血浆纤维蛋白原（FIB）、凝血酶原时间（PT）、凝血酶时间（TT）及活化部分凝血活酶时间（APTT）。
患者分为异常黏液质型68例、异常胆液质型34例、异常黑胆质型31例、异常血液质型26例。与对照组比较，异常黏液质组及非异常黏液质组（包括异常胆液质、异常黑胆质、异常血液质型）CD62p、PAI及ET-1水平升高，FIB及t-PA水平降低，PT延长，APTT缩短（均P<0.05）。组间比较CD41及TT差异无统计学意义（P>0.05）。与异常胆液质及异常血液质组比较，异常黏液质组ET-1水平升高（P<0.05）。与异常黑胆质组比较，异常黏液质组CD62p阳性率升高（P<0.05）。不同维吾尔医传统病症组患者CD41阳性率、t-PA或PAI-1含量、PT、TT及APTT差异无统计学意义（P>0.05）。
不同维吾尔医异常病症类型的恶性肿瘤患者均存在血栓前状态改变，表现为血管内皮细胞损伤、血小板活化、血液黏稠度增加、纤溶功能降低。其中异常黏液质组血栓前状态改变更明显。
