松果体：体外生物钟
The pineal gland: a biological clock in vitro.
作者信息
Binkley S A, Riebman J B, Reilly K B
出版信息
Science. 1978 Dec 15;202(4373):1198-20. doi: 10.1126/science.214852.
Circadian rhythmicity was studied by following the course of N-acetyl-transferase activity in the pineal glands of chickens in vitro. The results indicate (i) a daily change during day 1 of organ culture in constant dark that was dependent on the time the chickens were killed, (ii) equivocal persistence of the daily change in constant dark during 6 to 7 days of organ culture, (iii) an effect of light, (iv) inhibition by adrenergic agents and cycloheximide, and (v) stimulation by dibutyryl adenosine 3',5'-monophosphate and related compounds.
通过在体外追踪鸡松果体中N - 乙酰转移酶活性的变化过程来研究昼夜节律性。结果表明：（i）在持续黑暗条件下器官培养第1天存在每日变化，该变化取决于鸡被处死的时间；（ii）在器官培养6至7天的持续黑暗条件下，每日变化的持续性不明确；（iii）光照的影响；（iv）肾上腺素能药物和环己酰亚胺的抑制作用；以及（v）二丁酰腺苷3'，5'-单磷酸和相关化合物的刺激作用。
Zotero 插件