使用无量纲方程描述的流通池装置，实现双氯芬酸钠和盐酸罂粟碱从片剂和微丸中的同步释放。
Simultaneous release of diclofenac sodium and papaverine hydrochloride from tablets and pellets using the flow-through cell apparatus described by dimensionless equations.
作者信息
Kasperek Regina
机构信息
Department of Applied Pharmacy, Medical University of Lublin, 1 Chodźki St., 20-093 Lublin, Poland.
出版信息
Acta Pol Pharm. 2011 Mar-Apr;68(2):261-72.
The release of diclofenac sodium and papaverine hydrochloride from tablets and pellets using the flow-through cell apparatus was studied. The influence of excipients and of a size of the solid dosage forms on the amount of the released substances at the intervals of time using the different rates of flow of the dissolution medium was investigated. Physical parameters corresponding to the dissolution process as the mass transfer coefficient, the thickness of the boundary diffusion layer and the concentration of the saturated solution at this layer were calculated. The results of release were described by dimensionless equations.
采用流通池装置研究了双氯芬酸钠和盐酸罂粟碱从片剂和微丸中的释放情况。考察了辅料以及固体剂型尺寸对不同溶出介质流速下各时间间隔释放物量的影响。计算了与溶出过程相关的物理参数，如传质系数、边界扩散层厚度以及该层饱和溶液的浓度。释放结果用无量纲方程进行描述。
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