Liang Ming, Zhang Bin, Sun Wei, Xu Peng, Zhang Zhou, Yang Xiao-yu, Cao Xiao-rong, Hu Hong-liang, Li Zheng
Department of Urology/Shanghai Human Sperm Bank/Shanghai Institute of Androlog, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200001, China.
Zhonghua Nan Ke Xue. 2011 Mar;17(3):237-41.
To investigate and compare the incidences of birth defects in the offspring conceived by assisted reproductive technology (ART), including artificial insemination with the donor's semen (AID), in vitro fertilization with donor's semen (IVF-D) and intracytoplasmic sperm injection with the donor's semen (ICSI-D), and in those conceived through ART with the husband's semen, including AIH, IVF and ICSI, in order to further evaluate the safety of ART with the donor's semen.
From January 2005 to October 2009, Shanghai Human Sperm Bank provided sperm copies to 11 medical institutions, which resulted in a total of 904 offspring born by ART. We followed up all these cases and investigated the status of the offspring. The control group included 4195 offspring of infertile couples from 4 Reproductive Medical Centers approved by health management administrations, which were conceived by ART in the same period. After investigating the number of offspring and cases of birth defects caused by various methods of assisted reproductive technology, we compared the incidence of birth defects resulting from the donor's semen and that from the husband's.
There were 7 cases of birth defects (0.77%) in the offspring born by ART with the donor's semen, and 42 cases (1.00%) in those born by ART with the husband's semen, with no significant differences between the two groups (P > 0.05).
There were no significant differences in the category of birth defects between ART with the donor's semen and that with the husband's, while the incidence of birth defects resulting from ART with the donor's semen was significantly lower than that from ICSI in infertile couples. The present findings indicate a higher safety of ART with the donor's semen.
调查并比较辅助生殖技术（ART）受孕后代的出生缺陷发生率，包括供精人工授精（AID）、供精体外受精（IVF-D）和供精卵胞浆内单精子注射（ICSI-D），以及使用丈夫精液通过ART受孕的后代，包括夫精人工授精（AIH）、体外受精（IVF）和卵胞浆内单精子注射（ICSI），以进一步评估供精ART的安全性。
2005年1月至2009年10月，上海人类精子库向11家医疗机构提供精液样本，共产生904例ART出生的后代。我们对所有这些病例进行随访并调查后代情况。对照组包括来自4家经卫生管理部门批准的生殖医学中心的4195例不育夫妇的后代，他们在同一时期通过ART受孕。在调查了各种辅助生殖技术导致的后代数量和出生缺陷病例后，我们比较了供精和夫精导致的出生缺陷发生率。
供精ART出生的后代中有7例出生缺陷（0.77%），夫精ART出生的后代中有42例（1.00%），两组之间无显著差异（P>0.05）。
供精ART和夫精ART在出生缺陷类别上无显著差异，而不育夫妇中供精ART导致的出生缺陷发生率显著低于卵胞浆内单精子注射。目前的研究结果表明供精ART具有更高的安全性。
