具有潜在细胞生长抑制活性的新型1-苯基-6H-吡啶并[4,3-b]咔唑衍生物的合成
Synthesis of new 1-phenyl-6H-pyrido[4,3-b]carbazole derivatives with potential cytostatic activity.
作者信息
Tylińska Beata, Jasztold-Howorko Ryszard, Mastalarz Henryk, Szczaurska-Nowak Katarzyna, Materek Paulina, Wietrzyk Joanna
机构信息
Wrocław Medical University, Faculty of Pharmacy, Department of Organic Chemistry, Grodzka 9 St., 50-137 Wrocław, Poland.
出版信息
Acta Pol Pharm. 2011 Jan-Feb;68(1):31-7.
A number of new 1-substituted-6H-pyrido[4,3-b]carbazole derivatives have been synthesized. Nine of the newly obtained compounds were subjected to preliminary in vitro cytostatic activity screening against murine leukemia (L1210), human lung cancer (A549) and human colon cancer (HT29) cell lines. One particular compound 6f exhibited over 20 times better activity against L1210 tumor cell line than the reference ellipticine.
已经合成了许多新的1-取代-6H-吡啶并[4,3-b]咔唑衍生物。对新得到的9种化合物针对小鼠白血病（L1210）、人肺癌（A549）和人结肠癌（HT29）细胞系进行了初步的体外细胞生长抑制活性筛选。一种特定的化合物6f对L1210肿瘤细胞系的活性比参比物玫瑰树碱高20倍以上。
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