Formulation and evaluation of domperidone loaded mineral oil entrapped emulsion gel (MOEG) buoyant beads.

Alginate based mineral oil entrapped emulsion gel (MOEG) buoyant beads of domperidone were prepared by emulsion gelation technique. The prepared beads were evaluated for particle size, surface morphology, buoyancy, actual drug content and entrapment efficiency. Effect of different oils (castor oil, olive oil and linseed oil) and oil concentrations (10%, 15% and 20%, w/w) on uniformity, homogeneity and integrity of the beads was also studied. Density of the formulated beads was found to be ranging between 0.101 and 0.182 g/cm3. The results of the in vitro drug release indicated that linseed oil showed to be good release retardant compared to castor oil and olive oil. Moreover, the beads formulated using 15%, w/w linseed oil were more uniform in shape, exhibited maximum buoyancy and minimal oil leakage. Diffusion exponent (n) value varied from 0.4855 to 0.7710 indicating anomalous drug release behavior involving swelling, diffusion and/or erosion of the polymer matrix.