Zeybek B, Terek M C, Guven C, Cinar C
Department of Obstetrics and Gynecology, Ege University School of Medicine, Bornova, Izmir, Turkey.
Clin Exp Obstet Gynecol. 2011;38(1):96-8.
During pregnancy there are hemostatic changes that may result in a hypercoagulable state producing thrombotic consequences. This condition may be aggravated in women who are carriers of congenital thrombophilic factors. These factors may increase obstetric complications such as miscarriages, fetal growth restriction, placental abruption and preeclampsia. Trombophilic factors may also cause venous thromboembolism, which is the leading cause of maternal morbidity and mortality. We report a case of a 22-year-old woman with factor V Leiden mutation, whose pregnancy was complicated with deep venous thrombosis requiring placement of a vena cava filter.
孕期会出现止血变化，这可能导致血液高凝状态，进而引发血栓形成的后果。对于携带先天性血栓形成倾向因子的女性，这种情况可能会加重。这些因素可能会增加产科并发症的发生，如流产、胎儿生长受限、胎盘早剥和先兆子痫。血栓形成倾向因子还可能导致静脉血栓栓塞，这是孕产妇发病和死亡的主要原因。我们报告了一例22岁携带因子V莱顿突变的女性病例，其孕期并发深静脉血栓形成，需要植入下腔静脉滤器。
