Brenner Benjamin
Department of Hematology and Bone Marrow Transplantation, Rambam Medical Center, Haifa 31096, Israel.
Blood. 2004 Jun 1;103(11):4003-9. doi: 10.1182/blood-2003-08-2744. Epub 2004 Feb 12.
Pregnancy is a hypercoagulable state with an increased thrombotic risk throughout gestation and the postpartum period. Women with thrombophilia may have a further increased risk of placental vascular complications, including pregnancy loss, preeclampsia, intrauterine growth restriction, and placental abruption. Preliminary data suggest that maternal antithrombotic prophylaxis may result in improved gestational outcome. Randomized trials are under way and hopefully will optimize maternal and neonatal outcome.
妊娠是一种高凝状态，在整个妊娠期及产后血栓形成风险增加。患有血栓形成倾向的女性发生胎盘血管并发症的风险可能会进一步增加，包括流产、子痫前期、胎儿生长受限和胎盘早剥。初步数据表明，孕产妇抗血栓预防可能会改善妊娠结局。随机试验正在进行，有望优化孕产妇和新生儿结局。
