Nanosafety Research Center, Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland.
J Biomed Nanotechnol. 2011 Feb;7(1):19. doi: 10.1166/jbn.2011.1179.
It cannot be generally assumed that nanoparticles are genotoxic or that nanoscale size would increase the genotoxicity of the material. The large-scale in vivo genotoxicity testing of the various nanomaterials does not seem realistic. Information on nanoparticle characteristics associated with genotoxicity, carcinogenicity and mechanisms involved can probably be used in risk assessment.
不能一概认为纳米颗粒具有遗传毒性，也不能认为纳米尺寸会增加材料的遗传毒性。对各种纳米材料进行大规模的体内遗传毒性测试似乎不太现实。与遗传毒性、致癌性和相关机制相关的纳米颗粒特性信息可能可用于风险评估。
