Psychiatric Hospital of the University of Basel, Psychiatric Out-Patient Clinic, Basel, Switzerland.
World J Biol Psychiatry. 2012 Apr;13(4):259-68. doi: 10.3109/15622975.2011.562241. Epub 2011 Apr 12.
Sleep EEG spindles are linked to efficient cortical-subcortical connectivity and intellectual abilities. The aim of the present study was to investigate the relationship of spindle activity to psychosocial stress response and coping strategies in healthy kindergarten children.
In a cross-sectional study of 41 5-year old kindergarten children we examined stress-induced hypothalamic-pituitary-adrenocortical (HPA) system activity by saliva cortisol measurements and sleep regulation by sleep EEG-monitoring. Stress response was measured during the application of a standardized psychological challenge appropriate at this age. NREM S2 sleep EEG spindles were visually scored and put into relation to coping and HPA activity parameters.
An increased total number of NREM S2 sleep spindles correlated positively with increased high ego-involvement strategies such as "positive emotions". By contrast, total number of NREM S2 sleep spindles correlated negatively with low ego-involvement strategies such as "denial" and "avoidance". Stress induced HPA-activity correlated positively with coping strategies with high ego-involvement; while there was no correlation with low ego-involvement strategies.
Total number of visually detected NREM S2 sleep spindles is elevated in children with coping involving positive, high ego-involvement; in contrast, low ego-involvement during stress is associated with reduced total number of NREM S2 sleep spindles.
睡眠脑电图纺锤波与皮质下连接的效率和智力能力有关。本研究的目的是研究纺锤波活动与健康幼儿园儿童的心理社会应激反应和应对策略之间的关系。
在一项 41 名 5 岁幼儿园儿童的横断面研究中，我们通过唾液皮质醇测量来检查下丘脑-垂体-肾上腺皮质（HPA）系统的应激诱导活性，并通过睡眠脑电图监测来检查睡眠调节。在应用适合该年龄的标准化心理挑战期间测量应激反应。通过视觉评分 NREM S2 睡眠脑电图纺锤波，并将其与应对和 HPA 活动参数联系起来。
NREM S2 睡眠纺锤波总数增加与高自我卷入策略（如“积极情绪”）呈正相关。相比之下，NREM S2 睡眠纺锤波总数与低自我卷入策略（如“否认”和“回避”）呈负相关。应激诱导的 HPA 活性与高自我卷入的应对策略呈正相关；而与低自我卷入的应对策略则无相关性。
在涉及积极、高自我卷入的应对策略的儿童中，NREM S2 睡眠纺锤波总数增加；相反，在应激期间低自我卷入与 NREM S2 睡眠纺锤波总数减少有关。
