5-芳亚甲基-N,N-二甲基巴比妥酸的合成及 DPPH 自由基清除活性。
Synthesis and DPPH radical scavenging activity of 5-arylidene-N,N-dimethylbarbiturates.
机构信息
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.
出版信息
Med Chem. 2011 May;7(3):231-6. doi: 10.2174/157340611795564231.
PMID:21486204
Abstract
Twenty-four derivatives of N,N-dimethylbarbituric acid 1-24 were screened for their DPPH radical scavenging activity. These compounds showed an excellent antioxidant activity. A structure-activity relationship has been discussed, while all the synthetic compounds were characterized by spectroscopic techniques and elemental analysis.
摘要
对 N,N-二甲基巴比妥酸 1-24 的 24 种衍生物进行了 DPPH 自由基清除活性筛选。这些化合物表现出了极好的抗氧化活性。讨论了构效关系，而所有合成化合物均通过光谱技术和元素分析进行了表征。
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