Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Lipids Health Dis. 2011 Apr 12;10:54. doi: 10.1186/1476-511X-10-54.
It is well known that lipids abnormally accumulate in the alveoli during idiopathic pulmonary alveolar proteinosis (PAP). It is unclear, however, whether lipids also abnormally accumulate in serum. This study investigated the serum lipid panels in idiopathic PAP patients and explored the relationships between serum levels and the severity of idiopathic PAP.
Clinical data including the level of serum lipids were evaluated in 33 non-diabetic idiopathic PAP patients and 157 healthy volunteers. Serum levels of triglyceride were higher in PAP patients than in healthy subjects (median: 192.00 mg/dl (P25: 104.36, P75: 219.00) vs 119.56 mg/dl (P25: 78.81, P75: 193.03), P < 0.05), while high-density lipoprotein cholesterol (HDL-C) levels were lower in patients than in the control group (42.50 ± 10.30 vs 51.34 ± 12.06 mg/dl, P < 0.01). Forced expiratory volume in one second and forced vital capacity in hypertriglyceridemia patients were lower than those in patients with normal triglyceride. Serum LDL-C and HDL-C ratio correlated negatively with PaO2 (r = -0.403, P < 0.05) and positively with lactate dehydrogenase (r = 0.381, P < 0.05).
PAP associates with high triglyceride and low HDL levels in the serum, and these lipids provide potential intervention strategy for treatment.
特发性肺泡蛋白沉积症（PAP）患者的肺泡中异常积聚脂质是众所周知的。然而，目前尚不清楚血清中是否也异常积聚脂质。本研究调查了特发性 PAP 患者的血清脂质谱，并探讨了血清水平与特发性 PAP 严重程度之间的关系。
评估了 33 例非糖尿病特发性 PAP 患者和 157 名健康志愿者的临床数据，包括血清脂质水平。PAP 患者的血清甘油三酯水平高于健康对照组（中位数：192.00mg/dl（P25：104.36，P75：219.00）比 119.56mg/dl（P25：78.81，P75：193.03），P<0.05），而高密度脂蛋白胆固醇（HDL-C）水平低于对照组（42.50±10.30 vs 51.34±12.06mg/dl，P<0.01）。在高甘油三酯血症患者中，一秒用力呼气容积和用力肺活量均低于正常甘油三酯患者。血清 LDL-C 和 HDL-C 比值与 PaO2 呈负相关（r=-0.403，P<0.05），与乳酸脱氢酶呈正相关（r=0.381，P<0.05）。
PAP 与血清中高甘油三酯和低 HDL 水平相关，这些脂质为治疗提供了潜在的干预策略。
