Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
J Pharm Pharm Sci. 2010;13(4):524-35. doi: 10.18433/j3p306.
N-Methyl-2-pyrrolidone (NMP) or Pharmasolve is very strong solubilizing agent and it has important applications in different fields of industry. This review presents NMP physicochemical characteristics, application especially in pharmaceutical sciences, pharmacokinetic and toxicity. Characteristics of NMP such as physicochemical properties, solubilization efficacy, toxicity and adverse effects were compared with other common solvents used in the pharmaceutical industries. This review reveals that NMP is an acceptable pharmaceutical solvent and its efficacy, toxicity, and side effects are comparable with other common solvent.
N-甲基-2-吡咯烷酮（NMP）或 Pharmasolve 是一种非常强的增溶剂，在工业的不同领域有重要的应用。本综述介绍了 NMP 的物理化学特性、特别是在药物科学中的应用、药代动力学和毒性。将 NMP 的特性，如物理化学性质、增溶效果、毒性和不良反应与制药工业中常用的其他溶剂进行了比较。本综述表明，NMP 是一种可接受的药物溶剂，其功效、毒性和副作用与其他常见溶剂相当。
