Université Lille Nord de France, INSERM, U1011, Lille, France.
FEBS Lett. 2011 Jun 6;585(11):1640-50. doi: 10.1016/j.febslet.2011.03.066. Epub 2011 Apr 7.
Nuclear receptors (NRs) are molecular transducers of endocrine and dietary signals allowing tissues to adapt their transcriptional responses to endogenous or exogenous cues. These signals act in many cases as specific ligands, converting of NRs into transcriptionally active molecules. This on-off mechanism needs, however, to be finely tuned with respect to the tissue environment and adjusted to the organism needs. These subtle adjustments of NR transcriptional activity are brought about by post-translational modifications (PTMs), which can be, in the case of orphan NRs, the sole regulatory mechanism. The role of PTMs, with a more specific focus on phosphorylation, affecting the functions of NR controlling metabolic events is described in this review.
核受体（NRs）是内分泌和饮食信号的分子转导器，使组织能够将其转录反应适应内源性或外源性信号。这些信号在许多情况下作为特定配体起作用，将 NR 转化为转录活性分子。然而，这种开-关机制需要根据组织环境进行精细调节，并适应生物体的需要。NR 转录活性的这些细微调节是通过翻译后修饰（PTMs）实现的，对于孤儿 NR 而言，PTMs 是唯一的调节机制。本综述描述了 PTMs（更具体地说是磷酸化）在调节控制代谢事件的 NR 功能方面的作用。
