Department of Cardiology, The University of Texas, M.D. Anderson Cancer Center, TX 77030, USA.
FEBS Lett. 2011 Sep 16;585(18):2891-6. doi: 10.1016/j.febslet.2011.04.002. Epub 2011 Apr 8.
To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).
为了维持基因组完整性，细胞必须利用多种机制来保护其 DNA 免受环境因素或 DNA 代谢产生的损伤。SUMO（小泛素样修饰物）可以调节蛋白质稳定性、蛋白质细胞定位和蛋白质-蛋白质相互作用。在这篇综述中，我们总结了 SUMO 化和去 SUMO 化在 DNA 损伤反应 (DDR) 和 DNA 修复中的作用的最新认识，特别关注 RPA SUMO 化在同源重组 (HR) 中的作用。
