Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Retina. 2011 Sep;31(8):1603-8. doi: 10.1097/IAE.0b013e31820f4b39.
To evaluate the subfoveal choroidal thickness in the fellow eyes of patients with CSC, a disease often associated with choroidal vascular hyperpermeability even in eyes without subretinal fluid.
In this observational cross-sectional study, we measured the bilateral subfoveal choroidal thickness in patients with unilateral CSC using enhanced depth imaging spectral-domain optical coherence tomography. Areas of choroidal vascular hyperpermeability were visualized with indocyanine green angiography.
Sixty-six consecutive Japanese patients (50 men, 16 women; mean age, 52.8 years) with unilateral CSC were examined. The subfoveal choroid in symptomatic eyes was significantly thicker than that in fellow eye (414 ± 109 μm vs. 350 ± 116 μm, P < 0.001, respectively). The subfoveal choroid of eyes with choroidal vascular hyperpermeability was 410 ± 92 μm, which differed significantly (P < 0.001) from the choroid (239 ± 59 μm) of fellow eyes without choroidal vascular hyperpermeability.
The subfoveal choroid in the fellow eyes of patients with CSC was thicker in the eyes with choroidal vascular hyperpermeability. Enhanced depth imaging spectral-domain optical coherence tomography can assess the effects of choroidal vascular hyperpermeability by measuring the choroidal thickness noninvasively.
评估中心性浆液性脉络膜视网膜病变（CSC）患者对侧眼的脉络膜下厚度，即使在没有视网膜下积液的眼中，该疾病通常也与脉络膜血管通透性增加有关。
在这项观察性横断面研究中，我们使用增强深度成像谱域光相干断层扫描测量单侧 CSC 患者双侧的脉络膜下厚度。通过吲哚菁绿血管造影术观察脉络膜血管通透性增加的区域。
共检查了 66 例连续的日本 CSC 单侧患者（50 名男性，16 名女性；平均年龄 52.8 岁）。症状眼的脉络膜下厚度明显比对侧眼厚（414 ± 109μm 与 350 ± 116μm，P < 0.001）。脉络膜血管通透性增加眼的脉络膜下厚度为 410 ± 92μm，与无脉络膜血管通透性增加的对侧眼的脉络膜（239 ± 59μm）明显不同（P < 0.001）。
CSC 患者对侧眼的脉络膜下厚度在伴有脉络膜血管通透性增加的眼中较厚。增强深度成像谱域光相干断层扫描可以通过非侵入性测量脉络膜厚度来评估脉络膜血管通透性增加的影响。
