Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Med Biol Eng Comput. 2011 Aug;49(8):917-24. doi: 10.1007/s11517-011-0770-y. Epub 2011 Apr 13.
In earlier work, we suggested that the start of the isovolumic contraction period could be detected in arterial pressure waveforms as the start of a temporary pre-systolic pressure perturbation (AIC(start), start of the Arterially detected Isovolumic Contraction), and proposed the retrograde coronary blood volume flow in combination with a backwards traveling pressure wave as its most likely origin. In this study, we tested this hypothesis by means of a coronary artery occlusion protocol. In six Yorkshire × Landrace swine, we simultaneously occluded the left anterior descending (LAD) and left circumflex (LCx) artery for 5 s followed by a 20-s reperfusion period and repeated this sequence at least two more times. A similar procedure was used to occlude only the right coronary artery (RCA) and finally all three main coronary arteries simultaneously. None of the occlusion protocols caused a decrease in the arterial pressure perturbation in the aorta during occlusion (P > 0.20) nor an increase during reactive hyperemia (P > 0.22), despite a higher deceleration of coronary blood volume flow (P = 0.03) or increased coronary conductance (P = 0.04) during hyperemia. These results show that the pre-systolic aortic pressure perturbation does not originate from the coronary arteries.
在早期的工作中，我们提出可以在动脉压力波形中检测到等容收缩期的开始，作为一个暂时的收缩前期压力扰动的开始（AIC(start)，即动脉检测到的等容收缩期），并提出逆行冠状动脉血流结合反向传播压力波作为其最可能的起源。在这项研究中，我们通过冠状动脉阻塞方案来验证这一假设。在六头约克夏×长白猪中，我们同时阻塞左前降支（LAD）和左回旋支（LCx）动脉 5 秒，然后进行 20 秒的再灌注期，并至少重复两次这个序列。类似的程序用于阻塞右冠状动脉（RCA），最后同时阻塞所有三条主要冠状动脉。在阻塞期间，没有任何阻塞方案导致主动脉中动脉压力扰动减少（P > 0.20），在反应性充血期间也没有增加（P > 0.22），尽管在充血期间冠状动脉血流速度下降（P = 0.03）或冠状动脉传导性增加（P = 0.04）。这些结果表明，收缩前期主动脉压力扰动不是起源于冠状动脉。
