Department of Physiology, University of Manitoba, Winnipeg, Canada.
J Physiol Sci. 2011 Jul;61(4):331-6. doi: 10.1007/s12576-011-0147-x. Epub 2011 Apr 13.
We have investigated whether acute (swimming) exercise is sufficient to have sustained beneficial effects against cardiac functional decline observed after high-dose isoproterenol administration. Mice were subjected to one bout of swimming for 30 min ("swim" group). Twenty-four hours later, they were given isoproterenol (160 mg/kg) to cause injury. Two control groups were included, a shallow "water" group, for which no swimming took place, and a "cage" group; they were both given isoproterenol as in the "swim" group. Cardiac function was assessed by tissue Doppler imaging (TDI) 24 h, 2 weeks, and 4 weeks post-isoproterenol. Left ventricular (LV) systolic function including endocardial velocity and radial strain rate declined significantly in all groups at all time points after isoproterenol, compared with their pre-isoproterenol treatment values. The "swim" group, however, had significantly higher LV systolic function compared with either of the control groups at 24 h, and this improvement persisted 2 and 4 weeks post-treatment. There were no significant differences between the control groups at any time point. In conclusion, a single bout of swimming has sustained beneficial effects against injury, as measured by TDI, after administration of isoproterenol.
我们研究了急性（游泳）运动是否足以对高剂量异丙肾上腺素给药后观察到的心脏功能下降产生持续的有益影响。小鼠进行了 30 分钟的游泳运动（“游泳”组）。24 小时后，它们被给予异丙肾上腺素（160mg/kg）以造成损伤。包括一个浅的“水”组和一个“笼子”组在内的两个对照组，它们都像“游泳”组一样接受了异丙肾上腺素。通过组织多普勒成像（TDI）在异丙肾上腺素后 24 小时、2 周和 4 周评估心脏功能。与异丙肾上腺素治疗前相比，所有组在异丙肾上腺素后所有时间点的左心室（LV）收缩功能，包括心内膜速度和径向应变率均显著下降。然而，与两个对照组相比，“游泳”组在 24 小时时具有显著更高的 LV 收缩功能，这种改善在治疗后 2 周和 4 周持续存在。在任何时间点，对照组之间均无显著差异。总之，单次游泳运动对异丙肾上腺素给药后的损伤具有持续的有益影响，这可以通过 TDI 测量。
