Sano Teruo
Faculty of Agriculture and Life Science, Hirosaki University.
Uirusu. 2010 Dec;60(2):177-85. doi: 10.2222/jsv.60.177.
Viroids are autonomously replicating, small single-stranded circular RNA pathogens that cause diseases in infected, susceptible plants. They are non-coding RNA replicon which replicate depending on host transcriptional machinery and develop disease symptoms through interactions with cellular components of the host. The small size and unique molecular structure of viroid RNA makes them an attractive system to analyze molecular features responsible for pathogenesis, RNA transport, or molecular evolution and adaptation to specific host species. Here we show the latest progress in viroid research on new disease epidemics, molecular evolution and host adaptation, and pathogenesis in relation to viroid-induced RNA silencing.
类病毒是自主复制的小型单链环状RNA病原体，可在受感染的易感植物中引发疾病。它们是非编码RNA复制子，依靠宿主转录机制进行复制，并通过与宿主细胞成分相互作用产生疾病症状。类病毒RNA的小尺寸和独特分子结构使其成为分析致病、RNA转运、分子进化以及适应特定宿主物种等分子特征的有吸引力的系统。在此，我们展示了类病毒研究在新疾病流行、分子进化与宿主适应以及与类病毒诱导的RNA沉默相关的发病机制方面的最新进展。
