Institute of Medical Research and Medicinal Plant Studies, Yaounde, Cameroon.
Andrologia. 2012 Feb;44(1):53-8. doi: 10.1111/j.1439-0272.2010.01102.x. Epub 2011 Apr 13.
Mature male albino Wistar rats (180-210 g) were given aqueous extract of dry seeds of Aframomum melegueta K. Schum (Zingiberaceae) by gastric intubation during periods of 8 and 55 days. This was performed in two doses: 115 and 230 mg kg(-1) during 8 days and 115 mg kg(-1) during 55 days. Control rats received distilled water during the same periods. The animals were sacrificed and their blood, as well as testis, epididymis, seminal vesicle and prostate were collected and analysed. Results showed a significant increase in testosterone in serum and testis, cholesterol in testis, α-glucosidase in epididymis and fructose in seminal vesicle after 8 days of treatment of A. melegueta-treated rats (115 and 230 mg kg(-1) ). Results also showed that levels of cholesterol in testis, α-glucosidase in epididymis and fructose in seminal vesicle increased by 93.34%, 83.44% and 62.78%, respectively, after 55 days of A. melegueta treatment. From these findings, it was concluded that the aqueous extract of A. melegueta increased the secretions of epididymis and seminal vesicle, which are accessory sex organs.
成熟雄性白化 Wistar 大鼠（180-210 克）通过胃内插管在 8 天和 55 天期间给予非洲豆蔻干种子的水提取物（姜科）。这是分两个剂量进行的：8 天期间为 115 和 230 mg/kg，55 天期间为 115 mg/kg。对照大鼠在相同时期接受蒸馏水。处死动物，并收集和分析其血液以及睾丸、附睾、精囊和前列腺。结果表明，在 A. melegueta 处理大鼠（115 和 230 mg/kg）治疗 8 天后，血清和睾丸中的睾丸酮、睾丸中的胆固醇、附睾中的α-葡萄糖苷酶和精囊中的果糖显著增加。结果还表明，在 A. melegueta 处理 55 天后，睾丸中的胆固醇、附睾中的α-葡萄糖苷酶和精囊中的果糖分别增加了 93.34%、83.44%和 62.78%。从这些发现可以得出结论，非洲豆蔻的水提取物增加了附属性器官附睾和精囊的分泌。
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