Ilic Nebojsa M, Dey Moul, Poulev Alexander A, Logendra Sithes, Kuhn Peter E, Raskin Ilya
Institute of Food Technology, University of Novi Sad , Bulevar cara Lazara 1, 21 000 Novi Sad, Serbia.
J Agric Food Chem. 2014 Oct 29;62(43):10452-7. doi: 10.1021/jf5026086. Epub 2014 Oct 20.
The ethanolic extract of grains of paradise (Aframomum melegueta Schum, Zingiberaceae) has been evaluated for inhibitory activity on cyclooxygenase-2 (COX-2) enzyme, in vivo for the anti-inflammatory activity and expression of several pro-inflammatory genes. Bioactivity-guided fractionation showed that the most active COX-2 inhibitory compound in the extract was [6]-paradol. [6]-Shogaol, another compound from the extract, was the most active inhibitory compound in pro-inflammatory gene expression assays. In a rat paw edema model, the whole extract reduced inflammation by 49% at 1000 mg/kg. Major gingerols from the extract [6]-paradol, [6]-gingerol, and [6]-shogaol reduced inflammation by 20, 25 and 38%. respectively when administered individually at a dose of 150 mg/kg. [6]-Shogaol efficacy was at the level of aspirin, used as a positive control. Grains of paradise extract has demonstrated an anti-inflammatory activity, which is in part due to the inhibition of COX-2 enzyme activity and expression of pro-inflammatory genes.
对天堂椒（姜科非洲豆蔻，学名Aframomum melegueta Schum）的乙醇提取物进行了评估，检测其对环氧合酶-2（COX-2）的抑制活性、体内抗炎活性以及几种促炎基因的表达。生物活性导向分离显示，提取物中活性最强的COX-2抑制化合物是[6]-对二酚。提取物中的另一种化合物[6]-姜烯酚是促炎基因表达检测中活性最强的抑制化合物。在大鼠足爪水肿模型中，提取物在1000 mg/kg剂量时可使炎症减轻49%。提取物中的主要姜辣素[6]-对二酚、[6]-姜酚和[6]-姜烯酚在以150 mg/kg剂量单独给药时，分别使炎症减轻20%、25%和38%。[6]-姜烯酚的疗效与用作阳性对照的阿司匹林相当。天堂椒提取物已显示出抗炎活性，这部分归因于对COX-2酶活性和促炎基因表达的抑制。
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