McLean A R, Kirkwood T B
Laboratory of Mathematical Biology, National Institute for Medical Research, The Ridgeway, London, U.K.
J Theor Biol. 1990 Nov 21;147(2):177-203. doi: 10.1016/s0022-5193(05)80051-7.
We present a mathematical model of the activation and proliferation of a clone of T helper cells in response to a replicating antigen. This is able to show types of behaviour akin to persistent infection and to immune memory. This model is expanded to include the infection and destruction of activated T helper cells by human immunodeficiency virus and the growth of a population of circulating human immunodeficiency virus. The resulting model is used to investigate the circumstances under which the human immunodeficiency virus can destabilize persistent infections and destroy immune memory, and to illustrate the impact of antigenic stimulation of infected T helper cell clones upon human immunodeficiency virus replication rates.
我们提出了一个数学模型，用于描述T辅助细胞克隆在应对复制性抗原时的激活和增殖情况。该模型能够展现出类似于持续性感染和免疫记忆的行为类型。此模型进一步扩展，纳入了人类免疫缺陷病毒对活化T辅助细胞的感染和破坏，以及循环中的人类免疫缺陷病毒群体的生长情况。所得模型用于研究人类免疫缺陷病毒在何种情况下会破坏持续性感染并摧毁免疫记忆，以及阐明感染的T辅助细胞克隆的抗原刺激对人类免疫缺陷病毒复制率的影响。
