Klinik und Poliklinik für Neurologie, Universität Rostock, Gehlsheimer Strasse 20, Rostock, Germany.
Seizure. 2011 Sep;20(7):529-32. doi: 10.1016/j.seizure.2011.03.010. Epub 2011 Apr 12.
Nonconvulsive status epilepticus (NCSE) and epilepsia partialis continua (EPC) are common epileptic conditions for which straightforward recommendations based on controlled randomized trials for treatment in therapy refractory courses are lacking. In a large retrospective study on drug efficacy in status epilepticus (SE) we identified the patients treated in our department by searching for the term "status epilepticus" in the electronic archive of medical reports of our clinic. Here we present the subset of data concerning the patients treated with lacosamide (LCM). Ten episodes of SE in nine patients could be analyzed. To control for age dependency of results at discharge we calculated a Spearman correlation coefficient with age as independent variable and return to baseline Modified Rankin Score (mRS) at discharge=1, worsening of condition at discharge (i.e. new neurological deficit or worsening of mRS)=2 and death in hospital=3 as dependent variables. LCM was given in dosages of 50-100mg. It was not earlier administered than as fourth drug. Nevertheless it seemed to be effective for termination of status epilepticus in 20% of the episodes. But the outcome at discharge seemed considerably to depend on age of patients (r=0.94, explaining 89% of variance).
非惊厥性癫痫持续状态（NCSE）和部分性癫痫持续状态（EPC）是常见的癫痫病症，对于这些病症，缺乏基于对照随机试验的治疗方案，无法直接推荐。在一项关于癫痫持续状态（SE）药物疗效的大型回顾性研究中，我们通过在我们诊所的医疗报告电子档案中搜索“癫痫持续状态”一词，确定了在我们科室接受治疗的患者。在这里，我们介绍了有关使用拉考沙胺（LCM）治疗的患者数据子集。在 9 名患者中，有 10 例 SE 发作可以进行分析。为了控制出院时因年龄导致的结果依赖性，我们计算了斯皮尔曼相关系数，以年龄为自变量，出院时的改良 Rankin 评分（mRS）回归为 1（即无新的神经功能缺损或 mRS 恶化）、出院时病情恶化（即新的神经功能缺损或 mRS 恶化）和住院死亡为 3 个因变量。LCM 的剂量为 50-100mg。它不是作为第四种药物更早给药的。尽管如此，它似乎对终止 20%的癫痫持续状态发作有效。但出院时的结果似乎在很大程度上取决于患者的年龄（r=0.94，解释了 89%的方差）。
