Laboratoire de Nutrition, Département de Biologie Animale, Faculté des Sciences et Techniques, Université Cheikh Anta Diop de Dakar, Dakar, Senegal.
Am J Clin Nutr. 2011 Jun;93(6):1348-55. doi: 10.3945/ajcn.111.012278. Epub 2011 Apr 13.
Simple, low-cost methods are needed to evaluate the effect of zinc-fortification programs. Plasma zinc concentration is a useful biomarker of zinc intake from supplementation, but responses to zinc fortification are inconsistent.
The objective was to compare the change in plasma zinc concentrations in young children who received zinc from either a liquid supplement or a zinc-fortified complementary food.
A double-blind intervention trial was conducted in 137 young Senegalese children aged 9-17 mo who were randomly assigned to receive one of the following treatments for 15 d: 1) 30 g dry weight of an iron-fortified cereal porridge and a liquid multivitamin supplement without zinc (control group), 2) the same porridge and multivitamin supplement with 6 mg Zn added to the supplement dose (ZnSuppl group), or 3) the same porridge with added zinc to provide 6 mg Zn per 25 g dry weight of porridge and multivitamin without zinc (ZnFort group).
Mean (±SD) plasma zinc concentration (μg/dL) increased by 4.7 ± 1.6 (P = 0.004) in the ZnSuppl group, which was significantly greater (P = 0.009) than the mean change in the control group (-1.0 ± 1.6; P = 0.51) and in the ZnFort group (-1.8 ± 1.7; P = 0.29). The latter 2 groups did not differ from each other (P = 0.99).
Plasma zinc concentration increased in children who received daily zinc supplementation for 15 d but not in those who received a zinc-fortified complementary food containing a similar amount of zinc. Additional longer-term studies are needed to assess the effect of zinc-fortification programs on zinc-related functional outcomes and the usefulness of plasma zinc as a biomarker of program effect. This trial was registered at www.clinicaltrials.gov as study NCT0094398.
需要简单、低成本的方法来评估补锌项目的效果。血浆锌浓度是评估补充剂摄入锌的有用生物标志物，但补锌的反应并不一致。
本研究旨在比较接受液体补充剂或锌强化补充食品的幼儿血浆锌浓度的变化。
在 137 名 9-17 月龄的塞内加尔幼儿中进行了一项双盲干预试验，他们被随机分配接受以下治疗 15 天：1）30 克干重铁强化谷物粥和不含锌的液体多种维生素补充剂（对照组），2）相同的粥和多种维生素补充剂，补充剂量中添加 6 毫克锌（ZnSuppl 组），或 3）添加锌的相同粥，每份 25 克干重粥和多种维生素不含锌，提供 6 毫克锌（ZnFort 组）。
ZnSuppl 组的平均（±SD）血浆锌浓度（μg/dL）增加了 4.7±1.6（P=0.004），明显高于对照组（-1.0±1.6；P=0.51）和 ZnFort 组（-1.8±1.7；P=0.29）的平均变化。后两组之间没有差异（P=0.99）。
接受 15 天每日锌补充的儿童血浆锌浓度增加，但接受含有相似锌量的强化补充食品的儿童则不然。需要进行更多的长期研究来评估补锌计划对与锌相关的功能结果的影响，以及血浆锌作为计划效果生物标志物的有用性。本试验在 www.clinicaltrials.gov 上注册为 NCT0094398 号研究。
