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蛋白质与肾纤维化：低蛋白饮食诱导 Kruppel 样因子 15，限制肾纤维化。

Proteins and renal fibrosis: low-protein diets induce Kruppel-like factor-15, limiting renal fibrosis.

机构信息

Nephrology Division, Baylor College of Medicine, Houston, Texas 77030, USA.

出版信息

Kidney Int. 2011 May;79(9):933-4. doi: 10.1038/ki.2011.8.

DOI:10.1038/ki.2011.8
PMID:21490612
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3558977/
Abstract

The mechanisms underlying beneficial influences of low-protein diets on the progressive nature of chronic kidney disease are incompletely understood. Gao et al. identify a downregulation of Kruppel-like factor-15 (KLF15) associated with increased renal fibrosis. The KLF15 downregulation and renal fibrosis are reversed with dietary protein restriction, especially when ketoacids are added. The results suggest that KLF15 may play a role in suppressing renal fibrosis and could contribute to the benefits of dietary protein restriction.

摘要

低蛋白饮食对慢性肾脏病进行性发展的有益影响的机制尚不完全清楚。高等人发现，与肾纤维化增加相关的 Krüppel 样因子 15（KLF15）表达下调。饮食蛋白限制，尤其是添加酮酸可逆转 KLF15 下调和肾纤维化。这些结果提示 KLF15 可能在抑制肾纤维化中发挥作用，并有助于饮食蛋白限制的益处。

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Kidney Int. 2011 May;79(9):933-4. doi: 10.1038/ki.2011.8.
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引用本文的文献

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Krϋppel-like factors (KLFs) in renal physiology and disease.肾脏生理学和疾病中的 Krϋppel 样因子 (KLFs)。
EBioMedicine. 2019 Feb;40:743-750. doi: 10.1016/j.ebiom.2019.01.021. Epub 2019 Jan 17.
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Pregnancy, Proteinuria, Plant-Based Supplemented Diets and Focal Segmental Glomerulosclerosis: A Report on Three Cases and Critical Appraisal of the Literature.妊娠、蛋白尿、植物性补充饮食与局灶节段性肾小球硬化：三例报告及文献评价。
Nutrients. 2017 Jul 19;9(7):770. doi: 10.3390/nu9070770.
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SIRT3-KLF15 signaling ameliorates kidney injury induced by hypertension.SIRT3-KLF15信号通路可改善高血压所致的肾损伤。
Oncotarget. 2017 Jun 13;8(24):39592-39604. doi: 10.18632/oncotarget.17165.
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BMC Nephrol. 2016 Sep 20;17(1):132. doi: 10.1186/s12882-016-0339-y.
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本文引用的文献

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Low-protein diet supplemented with ketoacids reduces the severity of renal disease in 5/6 nephrectomized rats: a role for KLF15.低蛋白饮食联合酮酸可减轻 5/6 肾切除大鼠的肾脏疾病严重程度：KLF15 的作用。
Kidney Int. 2011 May;79(9):987-96. doi: 10.1038/ki.2010.539. Epub 2011 Jan 19.
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Satellite cell dysfunction and impaired IGF-1 signaling cause CKD-induced muscle atrophy.卫星细胞功能障碍和 IGF-1 信号受损导致 CKD 引起的肌肉萎缩。
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Long-term outcome on renal replacement therapy in patients who previously received a keto acid-supplemented very-low-protein diet.先前接受过补充酮酸的极低蛋白饮食患者的肾脏替代治疗长期预后
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Bicarbonate supplementation slows progression of CKD and improves nutritional status.补充碳酸氢盐可减缓慢性肾脏病的进展并改善营养状况。
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Low protein diets for chronic kidney disease in non diabetic adults.非糖尿病成年慢性肾病患者的低蛋白饮食
Cochrane Database Syst Rev. 2009 Jul 8(3):CD001892. doi: 10.1002/14651858.CD001892.pub3.
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Prevalence of chronic kidney disease in the United States.美国慢性肾脏病的患病率。
JAMA. 2007 Nov 7;298(17):2038-47. doi: 10.1001/jama.298.17.2038.
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Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes.慢性肾病和糖尿病肾脏病变的进展与消退机制。
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Nitrogen sparing induced by leucine compared with that induced by its keto analogue, alpha-ketoisocaproate, in fasting obese man.在禁食的肥胖男性中，亮氨酸诱导的氮节省与其酮类似物α-酮异己酸诱导的氮节省的比较。
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Dietary protein restriction in established renal injury in the rat. Selective role of glomerular capillary pressure in progressive glomerular dysfunction.大鼠已发生肾损伤时的饮食蛋白质限制。肾小球毛细血管压力在进行性肾小球功能障碍中的选择性作用。
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