蛋白质与肾纤维化：低蛋白饮食诱导 Kruppel 样因子 15，限制肾纤维化。
Proteins and renal fibrosis: low-protein diets induce Kruppel-like factor-15, limiting renal fibrosis.
机构信息
Nephrology Division, Baylor College of Medicine, Houston, Texas 77030, USA.
出版信息
Kidney Int. 2011 May;79(9):933-4. doi: 10.1038/ki.2011.8.
Abstract
The mechanisms underlying beneficial influences of low-protein diets on the progressive nature of chronic kidney disease are incompletely understood. Gao et al. identify a downregulation of Kruppel-like factor-15 (KLF15) associated with increased renal fibrosis. The KLF15 downregulation and renal fibrosis are reversed with dietary protein restriction, especially when ketoacids are added. The results suggest that KLF15 may play a role in suppressing renal fibrosis and could contribute to the benefits of dietary protein restriction.
摘要
低蛋白饮食对慢性肾脏病进行性发展的有益影响的机制尚不完全清楚。高等人发现，与肾纤维化增加相关的 Krüppel 样因子 15（KLF15）表达下调。饮食蛋白限制，尤其是添加酮酸可逆转 KLF15 下调和肾纤维化。这些结果提示 KLF15 可能在抑制肾纤维化中发挥作用，并有助于饮食蛋白限制的益处。
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