Jayalakshmi Sita, Sudhakar Pushpalatha, Panigrahi Manas
Department of Neurology, Krishna Institute of Medical Sciences, 1-8-31/1, Minister Road, Secunderabad, Andhra Pradesh 500 003, India.
Int J Mol Imaging. 2011;2011:803920. doi: 10.1155/2011/803920. Epub 2010 Dec 14.
Molecular imaging with ictal single photon emission computed tomography (SPECT) is an established functional imaging modality for the presurgical evaluation of patients with refractory partial onset seizures. SPECT coregistered on to the MRI has greater sensitivity to identify the ictal onset zone. Ictal SPECT should always be interpreted in the context of other presurgical investigations. Ictal SPECT is sensitive method for the lateralization of TLE, but ictal SPECT is more sensitive when MRI is normal. Ictal SPECT and interictal PET are complementary to each other in lateralizing the side in patients with TLE and normal MRI. In extratemporal epilepsy, ictal SPECT will guide the placement of surface grid and depth electrodes.
发作期单光子发射计算机断层扫描（SPECT）分子成像，是一种成熟的功能成像方式，用于难治性部分性发作患者的术前评估。与磁共振成像（MRI）进行配准的SPECT，在识别发作起始区方面具有更高的敏感性。发作期SPECT的解读应始终结合其他术前检查结果。发作期SPECT是颞叶癫痫（TLE）定侧的敏感方法，但当MRI正常时，发作期SPECT更为敏感。在TLE且MRI正常的患者中，发作期SPECT和发作间期正电子发射断层扫描（PET）在定侧方面互为补充。在颞叶外癫痫中，发作期SPECT将指导皮层电极和深部电极的放置。
