Duangjit Sureewan, Opanasopit Praneet, Rojanarata Theerasak, Ngawhirunpat Tanasait
Faculty of Pharmacy, Silpakorn University, Sanamchan Palace Campus, Nakhon Pathom 73000, Thailand.
J Drug Deliv. 2011;2011:418316. doi: 10.1155/2011/418316. Epub 2010 Nov 7.
The goal of this study was to develop and evaluate the potential use of liposome and transfersome vesicles in the transdermal drug delivery of meloxicam (MX). MX-loaded vesicles were prepared and evaluated for particle size, zeta potential, entrapment efficiency (%EE), loading efficiency, stability, and in vitro skin permeation. The vesicles were spherical in structure, 90 to 140 nm in size, and negatively charged (-23 to -43 mV). The %EE of MX in the vesicles ranged from 40 to 70%. Transfersomes provided a significantly higher skin permeation of MX compared to liposomes. Fourier Transform Infrared Spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC) analysis indicated that the application of transfersomes significantly disrupted the stratum corneum lipid. Our research suggests that MX-loaded transfersomes can be potentially used as a transdermal drug delivery system.
本研究的目的是开发并评估脂质体和传递体囊泡在美洛昔康（MX）经皮给药中的潜在应用。制备了载有MX的囊泡，并对其粒径、zeta电位、包封率（%EE）、负载效率、稳定性和体外皮肤渗透进行了评估。这些囊泡结构呈球形，大小为90至140纳米，带负电荷（-23至-43毫伏）。MX在囊泡中的%EE范围为40%至70%。与脂质体相比，传递体使MX的皮肤渗透显著更高。傅里叶变换红外光谱（FT-IR）和差示扫描量热法（DSC）分析表明，传递体的应用显著破坏了角质层脂质。我们的研究表明，载有MX的传递体有潜力用作经皮给药系统。
