Kawano Natsuko, Yoshida Kaoru, Miyado Kenji, Yoshida Manabu
Division of Gamete and Reproductive Biology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan.
J Lipids. 2011;2011:264706. doi: 10.1155/2011/264706. Epub 2011 Jan 12.
Cell membranes are composed of many different lipids and protein receptors, which are important for regulating intracellular functions and cell signaling. To orchestrate these activities, the cell membrane is compartmentalized into microdomains that are stably or transiently formed. These compartments are called "lipid rafts". In gamete cells that lack gene transcription, distribution of lipids and proteins on these lipid rafts is focused during changes in their structure and functions such as starting flagella movement and membrane fusion. In this paper, we describe the role of lipid rafts in gamete maturation, fertilization, and early embryogenesis.
细胞膜由许多不同的脂质和蛋白质受体组成，这些对于调节细胞内功能和细胞信号传导很重要。为了协调这些活动，细胞膜被分隔成稳定或短暂形成的微区。这些隔室被称为“脂筏”。在缺乏基因转录的配子细胞中，脂筏上脂质和蛋白质的分布在其结构和功能变化（如开始鞭毛运动和膜融合）过程中受到关注。在本文中，我们描述了脂筏在配子成熟、受精和早期胚胎发育中的作用。
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