磁共振波谱在乳腺癌诊断与治疗中的应用
MR Spectroscopy in the diagnosis and treatment of breast cancer.
作者信息
Nelson Michael T, Everson Lenore I, Garwood Michael, Emory Tim, Bolan Patrick J
机构信息
University of Minnesota Medical School, Department of Radiology, Center for Magnetic Resonance Imaging, Minneapolis, MN 55455.
出版信息
Semin Breast Dis. 2008 Jun 1;11(2):100-105. doi: 10.1053/j.sembd.2008.03.004.
Abstract
In vivo proton magnetic resonance spectroscopy ((1)H MRS) is rapidly becoming useful as a clinical tool for diagnosing and characterizing breast cancers. Alterations of the levels of choline-containing metabolites are associated with malignancy. High-field MR scanners at 1.5 T, 3 T, 4 T, and 7 T have been used to evaluate the role of (1)H MRS measurements of total choline containing compounds in patients with breast cancer. This article will review clinical use of MRI/MRS in vivo. Newer developments in high field MR scanning and quantitative MRS may help breast imagers improve sensitivity and specificity in diagnosing and treating breast cancer.
摘要
体内质子磁共振波谱（(1)H MRS）正迅速成为一种用于诊断和表征乳腺癌的临床工具。含胆碱代谢物水平的改变与恶性肿瘤相关。1.5T、3T、4T和7T的高场磁共振扫描仪已被用于评估(1)H MRS测量乳腺癌患者中总含胆碱化合物的作用。本文将综述MRI/MRS在体内的临床应用。高场磁共振扫描和定量MRS的最新进展可能有助于乳腺成像人员提高诊断和治疗乳腺癌的敏感性和特异性。
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